Purpose To analyze the relationship between visual field (VF) progression and baseline refraction in Japanese patients with primary open-angle glaucoma (POAG) including normal-tension glaucoma. (?1.93.8 diopter [D] vs ?3.53.4 D, P=0.0048) (mean standard deviation). When subject eyes were classified into four groups by the level of baseline refraction applying spherical equivalent (SE): no myopia (SE > ?1D), mild myopia (?1D SE > ?3D), moderate myopia (?3D SE > ?6D), and severe myopia (?6D SE), the CochranCArmitage JTT-705 trend analysis showed a decreasing trend in the proportion of MD slope deterioration with increasing severity of myopia (P=0.0002). The multivariate analysis revealed that baseline refraction (P=0.0108, odds ratio [OR]: 1.13, 95% confidence interval [CI]: 1.03C1.25) and intraocular pressure reduction rate (P=0.0150, OR: 0.97, 95% CI: 0.94C0.99) had a significant association with MD slope deterioration. Conclusion In the current analysis of JTT-705 Japanese patients with POAG, baseline refraction was a factor significantly associated with MD slope deterioration as well as intraocular pressure reduction rate. When baseline refraction was JTT-705 classified into four groups, MD slope in myopia groups was less deteriorated as compared to those in the emmetropic/hyperopic group. Keywords: primary open-angle glaucoma, normal-tension glaucoma, myopia, refraction, visual field progression, MD slope, intraocular JTT-705 pressure reduction rate Introduction Several epidemiologic studies have focused on the relationship between myopia and development of open-angle glaucoma (OAG).1C12 In the Tajimi Study,8 myopia (odds ratio [OR]: 1.85, 95% confidence interval [CI]: 1.03C3.31 for low myopia; OR: 2.60, 95% CI: 1.56C4.35 for moderate to high myopia) as well as higher intraocular pressure (IOP) (OR: 1.12, 95% CI: 1.04C1.21) and older age (OR: 1.06, 95% CI: 1.04C1.08) were identified as significant risk factors for having primary open-angle glaucoma (POAG). A meta-analysis of myopia as a risk factor for OAG, which combined data from eleven population-based cross-sectional studies, also found a pooled OR of 1 1.92 (95% CI: 1.54C2.38)4 and concluded that patients with myopia have an increased risk of developing OAG. On the other hand, there is controversy with regard to whether myopia is a risk factor for visual field (VF) progression in OAG. Several studies have reported that myopia is a risk factor for the progression.13C15 In contrast, a couple of studies have reported that myopia is not a risk factor16C18 or that myopia is even a preventive factor for VF progression in OAG.19C21 In Japan, the majority of glaucoma is POAG, particularly normal-tension glaucoma (NTG).22,23 The prevalence of myopia is also high in Japan.24 Understanding the relationship between myopia and VF progression in POAG may be a clue to proceed with intensive treatment. Hence, the aim of this analysis was to analyze the association between baseline refraction and VF progression JTT-705 by utilizing the longitudinal data of our retrospective observational study.25 Furthermore, we divided the subject eyes into four myopia groups by baseline refraction and analyzed the association between myopia and VF progression. Patients and methods Study design This was a multicenter, retrospective, observational study. Subjects The subjects in this analysis were based on our Rabbit Polyclonal to HUNK previous study data.25 The protocol for this study was approved in advance by the Institutional Review Board of Nihonmatsu Eye Hospital. Informed consent was obtained from the subjects after a thorough explanation of the study objective and information collection was given in accordance with ethical principles based on the Helsinki Declaration. Test data were collected separately by each participating facility. Briefly, all subjects were patients with POAG or NTG, and one eye from each subject which met the inclusion criteria and did not fulfill the exclusion criteria was selected. If both eyes met the inclusion criteria, the eye with.