Data Availability StatementAll data generated or analysed in this scholarly research are one of them published content. from the tumor pounds The doseCresponse romantic relationship of different tumor types on the partnership between BBR and tumor pounds of animals is certainly proven in Fig.?7. For one cancers types, a statistically significant linear romantic relationship in lung tumor (Pearson r?=???0.9623, were missing in breast malignancy group and liver malignancy group due to limited studies. No potential influencing factor was found in colorectal cancer group. Open in a separate windows Fig. 11 Forsythin Subgroup analyses of the body weight The doseCresponse relationship of different cancer types on the relationship between BBR and body weight of animals is usually shown in Fig.?12. For single cancer types, no statistically significant linear relationship was found. For Forsythin total studies, the SMD values of all studies showed no IgM Isotype Control antibody (APC) statistically significant pattern(Pearson Forsythin r?=???0.1440, were missing because of the limited studies. Secondly, generally speaking, obviously significant publication bias was not found based on the funnel plot (Fig.?13). However, poor symmetry of the funnel plot on tumor volume suggested more high-quality researches should be included. Thirdly, although PubMed, Embase, Springer, and Cochrane databases had been carefully and comprehensively searched, articles selected for each malignancy type were still small which could lead to bias. Fourthly, the anticancer effects of berberine in humans were not identified clearly and further studies in humans were needed to develop it as an anticancer agent. Conclusion BBR exerted anti-tumor effects in a variety of tumors in vivo, especially for breast malignancy and lung cancer. However, evidence was still insufficient in colorectal cancer and gastric cancer. One of its anti-tumor mechanisms was anti-angiogenesis. There was a dose-response relationship in the anti-tumor effects. Acknowledgements The current study was funded by the Kunshan first people s hospital affiliated to Jiangsu University, and the second affiliated hospital of Soochow University. Abbreviations BBRBerberineBWBody WeightCIConfidence IntervalDMSODimethyl SulfoxideEBNA1Epstein-Barr computer virus nuclear antigen 1ROSReactive Oxygen SpeciesSDStandard DifferenceSMDStandard Mean DifferenceTRAILTNF-related apoptosis-inducing ligandTVTumor VolumeTWTumor WeightVASPVasodilator-Stimulated PhosphoproteinVDVessel Density Authors contributions XJH and ZYS designed this study. XJH, LYM, YXY and NLW collected and analyzed the info. XJH, YN and WRH drafted the manuscript. XJH, ZYS and TJL interpreted the info and revised the manuscript. All authors have accepted and browse the manuscript. Funding The existing research was backed by grants or loans from the next affiliated medical center of Soochow college or university pre-research task (SDFEYGJ1609), the next affiliated medical center of Soochow college or university clinical self-discipline group task financing (XKQ 2015008), the worldwide group of gastrointestinal tumor task funding (SZYJTD201804) as well as the task from national essential laboratory of rays medicine (GZK1201820). The funder got no function in the look from the scholarly research and collection, evaluation, and interpretation of data and on paper the manuscript. Option of data and components All data generated or analysed in this scholarly research are one of them published content. Ethics consent and acceptance to participate Not applicable. Consent for publication Not really applicable. Competing passions The writers declare they have no contending interests. Footnotes Web publishers Note Springer Character remains neutral in regards to to jurisdictional promises in released maps and institutional affiliations. Jianhao Xu and Yuming Long contributed to the function equally. Yuming Long may be the co-first author..