Purpose This paper reports on presentations and conversation from the working group on “Influences on Sedentary Behavior & Interventions” as part of the Sedentary Behavior: Identifying Research Priorities Workshop. time (e.g. allowing employees regular desk breaks) or by changing norms surrounding prolonged sitting (e.g. standing meetings). Results & Conclusions You will find limited data about the minimal amount of SB switch required to produce meaningful health benefits. In addition to developing relevant scientific and public health definitions of SB it is important to further delineate the scope of health and quality of life outcomes associated with reduced SB across the life course and clarify what behavioral alternatives to SB can be used to optimize health gains. SB interventions will benefit from having more clarity about the potential physiological and behavioral synergies with current PA recommendations developing multi-level interventions aimed at reducing SB across all life phases and contexts harnessing relevant and effective strategies to lengthen the reach PTC-209 of interventions to all sectors of society as well as applying state-of-the-science adaptive designs and methods to accelerate improvements in the science of sedentary behavior interventions. Keywords: physical activity sedentary behavior sitting behavior switch This paper reports around the proceedings as part of a joint workshop sponsored and organized by the National Heart Lung and Blood Institute and National Institute on Aging entitled the “Influences on Sedentary Behavior/Interventions to reduce sedentary behavior”. A panel of experts in behavioral health PA interventions and health information technology to increase activity levels convened to discuss the PTC-209 major factors that might influence interventions for reducing sedentary behaviors. This workshop was not convened to conduct a systematic review of the literature since there are several recent publications that have carried out so (observe (7 10 21 31 37 The working group used an overarching framework involving literature reviews and discussions aimed at elucidating the “WHAT HOW with WHOM in what CONTEXT and with WHAT EFFECT” of interventions for reducing sedentary behavior. This central framework was expanded through bimonthly conference calls and email discussions. Recommendations evolved from this activity were discussed and offered to an international group of sedentary behavior experts who participated in a 2.5-hour webinar workshop and were altered according to the discussion that ensued. It is important to recognize that interventions are substantially influenced by the specific definitions of sedentary behavior that are being applied and which contribute to elevated health risk. For example the recommendations put forth below should generally apply PTC-209 to a definition of SB that is restricted to activities with intensities ≤1.5 metabolic equivalents or to activities CD59 that also consider posture (standing vs. sitting or reclining posture). Recommendation 1 There is a need to evaluate the feasibility acceptability and effectiveness of different SB intervention strategies across the life course; population diversity (emphasizing a range of sample characteristics) should be a key feature of study design that includes different age and cultural groups as well as life phases and functions to address the continued problem of health disparities. Rationale Sedentary behaviors at any age may have important proximal and distal effects for health and well-being. Thus a persuasive case can be made for SB interventions that consider a life course perspective. Additionally risk and risk perceptions often change across the lifespan and can be targeted in developing specific age- or life course-related SB interventions (observe Figure 1). Physique 1 Daily hours in sedentary behavior across the lifespan according to accelerometer data collected by the National Health and Nutrition Examination Survey (NHANES). Sedentary behavior is usually variable across the lifespan and this could have implications on designing … Age health status interpersonal and environmental contexts and life roles are expected to moderate the acceptability and effectiveness of any SB intervention. A useful goal is usually to explore components of interventions that may generalize across age groups and life situations thereby enhancing subsequent effects on population health. Additionally the specific health effects of an intervention PTC-209 are expected to vary in each phase of life – e.g..